Semaglutide vs Tirzepatide: Which One Fits Your Goals
Semaglutide is the proven weekly GLP-1 at the lower price and tirzepatide is the dual action option with the larger average loss in clinical trials.
Semaglutide and tirzepatide are both once weekly injections that help you eat less and lose weight. One is the proven GLP-1 at the lower price. The other is the dual action option with the bigger numbers in clinical trials. Here is how to pick the one that fits your goals.
Is this you?
Sound familiar?
You are wiped out after every meal.
You snack at night and hate it in the morning.
The 3 pm slump hits like a wall.
Your favorite jeans live in the back of the closet.
You have tried every diet and the scale will not move.
Clinic visits and waiting rooms do not fit your life.
You work shifts, or the nearest specialist is an hour away.
You want your energy back and to feel like yourself again.
If you nodded at two or three of those, this was built for you. Keep going.
How semaglutide works
Semaglutide is a GLP-1 receptor agonist. It mimics a hormone your gut releases after a meal, which tells your brain you are full and slows how fast your stomach empties. Appetite gets quieter. Portions shrink without a fight. The 9 pm snack run stops sounding like a good idea.
In clinical trials, semaglutide helped people lose about 15% of their body weight on average over 68 weeks. That comes from the STEP 1 trial, and it is the reason semaglutide became the medication everyone knows.
It is also the lower priced option. On the PepHaūs 6-month plan semaglutide is $152 a month with the provider visit and shipping included. That is a proven weekly GLP-1 for about five dollars a day.
How tirzepatide works
Tirzepatide does what semaglutide does and adds a second pathway. It activates GLP-1 and GIP receptors at the same time. GIP is another gut hormone, and the two together support appetite control and how your body handles blood sugar. Think of it as two hands on the wheel instead of one.
In clinical trials, tirzepatide helped people lose about 20% of their body weight on average at the top dose over 72 weeks. That comes from the SURMOUNT-1 trial. It is why tirzepatide gets called the stronger option.
Tirzepatide is $239 for your first month through PepHaūs, and the 3-month plan brings that to $227 and the 6-month plan to $215 a month.
Ready when you are. Ten minutes on your phone.
Start my online visitWhich one fits your goals
Both are wins. The question is which win you want.
Semaglutide is a great fit when you want the proven option at the lower price. It has the longest track record of the two. Many people reach their goal on semaglutide alone and never feel the need to switch.
Tirzepatide is a great fit when you want the dual action option with the larger average loss in clinical trials. Many people choose it when they have more weight to lose or want the extra push from day one.
Either way you are getting a once weekly injection with a small needle. Your provider starts low and steps up slowly, which is how most people stay comfortable. And the provider visit and shipping are included with both.
How a provider helps you choose
You do not have to figure this out alone. Your PepHaūs provider looks at your goals and your health history. Budget matters too, and your provider will tell you straight which option makes sense for the number you have in mind.
Many people start on semaglutide and move to tirzepatide later. Others start with tirzepatide from day one. Your provider can adjust as you go, and every change happens online without a clinic visit. For a deeper side by side, read our tirzepatide vs semaglutide comparison.
Pricing
What it costs
The provider visit and shipping are included in every price. Nothing gets added at checkout.
Pricing in your door
One price. Provider visit, medication and shipping included.
- First month$239
- 3-month plan$227/mo
- 6-month plan$215/mo
- First month$169
- 3-month plan$160/mo
- 6-month plan$152/mo
- Provider visit
- Medication
- Cold shipping to your door
- Refills on a schedule
- Care team messaging
- Cancel anytime online
LegitScript certified
A real U.S. pharmacy vs the grey market
Search either name online and you will find overseas vials labeled for research use only. No pharmacy behind it. Nobody prescribing it. Zero testing. You are guessing at what is in the vial and how it was handled on the way to you.
PepHaūs is the opposite of that. We are LegitScript certified. Your medication is compounded by a U.S.-licensed pharmacy and prescribed by a U.S.-licensed physician who reviews your intake. You get real care from real people inside the U.S. healthcare system.
FAQ
FAQ
Can I switch from semaglutide to tirzepatide?+
Yes. Many people start on semaglutide and move to tirzepatide later. Your provider handles the switch online and sets the new starting dose.
Do both require weekly injections?+
Yes. Both are once a week with a small needle you use at home. Most people find it takes less than a minute.
Why does tirzepatide cost more?+
Tirzepatide works on two receptors instead of one, and it posted the larger average loss in clinical trials. Many people feel that difference is worth the added cost.
What about side effects?+
Mild nausea in the first weeks is the most common thing people mention. Your provider starts low and steps up slowly, which is how most people stay comfortable while their body adjusts.
Do I need to see a doctor in person?+
No. A U.S.-licensed physician reviews your online intake and writes the prescription if it fits your goals. Everything from the visit to the shipping happens online.
How much can I expect to lose?+
In clinical trials semaglutide averaged about 15% body weight loss over 68 weeks. Tirzepatide averaged about 20% at the top dose over 72 weeks. Your provider helps you set a goal that fits your life. Both options get you moving toward the same place. Start your online visit and a U.S.-licensed physician will help you choose. Want the details first? Read more about semaglutide and tirzepatide .
Start your visit from your phone
Ten minutes on your phone. A physician licensed in your state. A box on your porch in 2 to 3 business days.
See if you qualifyYour care team
Every PepHaus visit is reviewed by a licensed physician from the Wasef Health Group provider network. A doctor reads your intake, decides if treatment fits, and sets your plan.
Meet the physiciansThis article is educational and is not medical advice. Compounded medications are not FDA-approved. Treatment requires evaluation by a licensed provider.