Sermorelin vs NAD+ for Longevity: What Works for You
Sermorelin supports sleep, recovery and body composition through growth hormone. NAD+ fuels cellular energy and mental clarity.
Sermorelin vs NAD+ for Longevity: What Works for You
You want to feel better, recover faster and keep your edge as you age. Sermorelin and NAD+ both show up in longevity conversations, and each does something different for how your body ages. Sermorelin signals your pituitary to release growth hormone in its natural nightly pulse, which supports deeper sleep, recovery and lean body composition. NAD+ is a coenzyme every cell needs to make energy and repair DNA, and your levels drop as you age. One works on your hormones, the other on your cells, and many people use both because they complement each other instead of overlapping.
Is this you?
Is this you?
You are looking at ways to stay sharp, strong and energized as you get into your 40s, 50s or beyond. You want results from what you take, not guesses or hype. You have heard about peptides and NAD+ but the information out there feels scattered or sales-focused. You want to know what each one actually does and whether one is better for what you need. You are willing to put in the work with training, sleep and protein, and you want something that supports that effort. If you nodded at two or three of those, keep reading.
Sermorelin, prescribed online from $143/mo
A nightly at home shot. Provider visit and shipping included. Nothing charged unless you are prescribed.
What sermorelin does and how it works
Sermorelin is a growth hormone releasing hormone analog. It signals your pituitary gland to release the growth hormone your body already makes, in the same natural pulse that happens when you sleep. It is not HGH, not a steroid and not testosterone. It does not raise testosterone. What it does is support the nightly GH pulse that drives recovery, deep sleep and lean body composition.
Most people report deeper sleep within the first two weeks. That is when growth hormone does its work, so better sleep means your body gets the recovery window it needs. You may notice you wake up less at night and feel more rested. Recovery after training improves around week four to six. Soreness clears faster and you can train harder without feeling wrecked. Lean body composition changes show up around month two to three when paired with consistent training and enough protein.
Sermorelin is prescribed by a U.S. licensed physician after a provider review and compounded by a U.S. licensed pharmacy. You inject it subcutaneously, about five to seven nights a week, right before bed. PepHaūs offers it from $143 a month with the provider visit and shipping included.
What NAD+ does and how it works
NAD+ is nicotinamide adenine dinucleotide, a coenzyme found in every cell. Your cells need it to turn food into energy and to repair DNA. Your NAD+ levels drop as you age, which shows up as lower energy, slower recovery and more brain fog. NAD+ injections raise those levels back up so your cells can do their work.
People report sharper focus and steadier energy within the first week or two. It is not a stimulant, so you do not get a jolt, but you may notice you can think clearly for longer stretches and you do not hit the afternoon wall as hard. Physical recovery improves too. Your muscles bounce back faster after training and you feel less wiped after a hard week. Some people report better mood and less of that flat, low-energy feeling.
NAD+ injections are prescribed after a provider review and compounded by a U.S. licensed pharmacy. You inject subcutaneously or intramuscularly, once or twice a week depending on your dose and how you feel. PepHaūs offers it from $179 a month with the provider visit and shipping included.
Ready when you are. Ten minutes on your phone.
Start my online visitThe main differences
Sermorelin works on your hormones. It signals your pituitary to release growth hormone, which supports sleep, recovery and lean body composition. NAD+ works on your cells. It fuels energy production and DNA repair, which supports focus, energy and recovery at the cellular level.
Sermorelin is taken almost every night because growth hormone is released in a nightly pulse. NAD+ is taken once or twice a week because the levels stay elevated for several days after an injection.
Sermorelin shows up first in your sleep quality, then recovery, then body composition over a few months. NAD+ shows up first in your focus and energy, then physical recovery, usually within a couple of weeks.
Can you use both
Yes, and many people do. They work on different systems and support each other. Sermorelin supports the nightly GH pulse that drives recovery and lean muscle. NAD+ fuels the cells so they can use that recovery window well. You take sermorelin at night and NAD+ on a schedule that works for you, often once or twice a week.
Your provider can review both and help you decide if using them together makes sense. Some people start with one, see how they respond and add the other a few months later. Others start with both if they want to address sleep, recovery, energy and focus at the same time.
The real thing vs the rest
Gummies and GLP-1 pills are not the same thing
You may see gummies or pills marketed as easier ways to take GLP-1s like tirzepatide or semaglutide. They were never in the clinical trials. When you swallow a peptide, your stomach breaks it down and about one percent reaches your blood. When you inject it, about 80 percent does. Injectable tirzepatide showed about 20 percent average body weight loss in clinical trials and semaglutide about 15 percent. The gummies and pills do not have that evidence.
The real thing vs the rest
A capsule cannot do this.
An injection prescribed by a physician puts the compound where it needs to go. A capsule or drink from an ad mostly does not survive digestion, and a grey market vial has nobody standing behind it.
Gummies and drinks
0 mg
No prescription compound inside.
Liposomal capsules
about 1%
Swallow it and about 1 of every 100 units reaches your blood.
Weekly injection
about 80%
Absorbed from the fat layer. Nothing in the way.
Swallow it: about 1% reaches your blood. Inject it: about 80% does. Same comparison we show on our homepage.
| What you get | PepHaūs prescription | Liposomal capsules and drinks | Grey market vials |
|---|---|---|---|
| Goes straight into your system | Unknown | ||
| Physician licensed in your state | |||
| U.S.-licensed pharmacy | |||
| Tested product, cold shipped | |||
| Provider visit included | |||
| Dose tuned to you |
Pricing
What it costs
Sermorelin is $159 for your first month, then $151 if you stay on for three months, $143 if you stay on for six. NAD+ is $199 for your first month, $189 for three months, $179 for six. The provider visit and shipping are included. There is never a doctor fee or a membership.
You can see pricing for each at /sermorelin and /nad. If you want both, your provider reviews you once and prescribes what fits.
Pricing in your door
One price. Provider visit, medication and shipping included.
- First month$159
- 3-month plan$151/mo
- 6-month plan$143/mo
- Provider visit
- Medication
- Cold shipping to your door
- Refills on a schedule
- Care team messaging
- Cancel anytime online
LegitScript certified
A licensed U.S. pharmacy vs the grey market
Overseas research vials sold as NAD+ or sermorelin are not compounded by a licensed pharmacy, not prescribed by a licensed provider and not tested the way a U.S. pharmacy product is. You do not know the dose, the purity or what else is in the vial. The grey market looks cheaper until something goes wrong and you have no one to call.
PepHaūs works with U.S. licensed pharmacies and U.S. licensed physicians. Every dose is compounded fresh, tested and shipped from a licensed facility. You get a provider review before you start and support while you are on it.
FAQ
FAQ
Which one is better for energy?+
NAD+ usually shows up faster for mental energy and focus. Sermorelin supports energy through better sleep and recovery, which builds over time.
Can I take sermorelin if I am already on TRT?+
Yes. Sermorelin does not raise testosterone, and many people on TRT use it for sleep and recovery. Your provider reviews your full picture before prescribing.
How long do I stay on each?+
Most people use sermorelin for at least six months to see full changes in body composition. NAD+ can be used ongoing or cycled depending on your goals. Your provider helps you decide.
Do I need lab work?+
Your provider may ask for recent labs if you have them, but it is not required to start. Some people get labs a few months in to track progress.
Which one helps with muscle?+
Sermorelin supports lean body composition and recovery, which helps you train harder and retain muscle when paired with protein and resistance training. NAD+ supports cellular energy, which helps recovery but does not directly drive muscle growth.
Can women use both?+
Yes. Both sermorelin and NAD+ are prescribed to women after a provider review.
What if I want to try one first?+
Start with whichever matches what you want most. If sleep and recovery are your main goals, sermorelin. If mental clarity and steady energy are your main goals, NAD+. You can always add the other later. You can start with either sermorelin at /sermorelin or NAD+ at /nad . A provider reviews your information and prescribes what fits, usually within 24 hours. Both are compounded by a U.S. licensed pharmacy and shipped free to your door.
Start your visit from your phone
Ten minutes on your phone. A physician licensed in your state. A box on your porch in 2 to 3 business days.
See if you qualifyYour care team
Every PepHaus visit is reviewed by a licensed physician from the Wasef Health Group provider network. A doctor reads your intake, decides if treatment fits, and sets your plan.
Meet the physiciansThis article is educational and is not medical advice. Compounded medications are not FDA-approved. Treatment requires evaluation by a licensed provider.