Safety information

What to know about sermorelin.

Most patients tolerate sermorelin well. The most common reactions are mild injection-site sensations and transient flushing that resolve quickly. Many patients report improved sleep quality within the first few weeks. Below is the prescribing information your provider will review with you before you start. Take a moment to read it, save the page, and bring up anything that feels unclear during your consultation.

Mild

Most reported reactions are mild. Usually injection-site warmth or a brief flush after dosing.

Take at night

Sermorelin is dosed before bed to align with your natural growth hormone pulse during deep sleep.

Ask anytime

Message your provider any time in the portal. They respond within business hours.

Full prescribing information below

Indications

Sermorelin is a growth hormone-releasing hormone (GHRH) analog that signals the pituitary to release endogenous growth hormone. It is prescribed in support of sleep quality, recovery, and body composition. Your U.S.-licensed provider makes the final determination whether sermorelin is appropriate based on your complete medical history.

Contraindications

Do not use sermorelin if you:

Are allergic to sermorelin or any of its ingredients
Are pregnant, planning to become pregnant, or breastfeeding
Have an active or recent diagnosis of cancer (theoretical concern; growth hormone may stimulate tumor cells)
Have unmanaged diabetes or active diabetic retinopathy
Have severe respiratory impairment, including acute critical illness
Are under 18 years of age

Warnings & Precautions

The following risks should be discussed with your provider before starting and monitored throughout treatment:

Theoretical concerns with active malignancy
Growth hormone may stimulate growth of certain cancer cells. Sermorelin is not recommended in patients with active or recent cancer.
Glucose intolerance
Growth hormone can affect insulin sensitivity. Diabetic patients should monitor blood glucose carefully.
Thyroid function changes
Sermorelin can occasionally affect thyroid hormone levels. Your provider may monitor thyroid function during treatment.
Hypersensitivity reactions
Discontinue and seek care for anaphylaxis, angioedema, or severe rash.
Injection-site reactions
Mild redness, warmth, swelling, or pain at the injection site is common and usually resolves within hours.
Sleep changes
Some patients report unusually vivid dreams during the first few weeks. This typically settles.

Common Side Effects

Commonly reported side effects of sermorelin are typically mild and short-lived:

Injection-site reaction

Flushing

Headache

Vivid dreams

Transient sleepiness

Mild nausea

Dizziness

Symptoms typically improve with time. Your provider will adjust your dose to minimize side effects.

Drug Interactions

Tell your provider about every medication you take, especially insulin and oral diabetes medications (sermorelin may affect blood glucose), thyroid hormone medications, and corticosteroids (which can blunt the response to sermorelin).

Pregnancy, Lactation, Fertility

Sermorelin is not recommended during pregnancy or while breastfeeding because it has not been adequately studied in these populations. Discuss with your provider if you are pregnant or planning to become pregnant.

Storage & Handling

Store unopened vials refrigerated at 36 to 46°F (2 to 8°C). Once opened, follow the instructions provided with your shipment. Do not freeze. Protect from light. Dispose of used needles and syringes in an approved sharps container.

Compounded Medication Disclosure

This product is a compounded preparation dispensed by a U.S.-licensed 503A compounding pharmacy. Compounded drugs are not FDA-approved, are not evaluated by FDA for safety or effectiveness, and are prepared for an identified individual patient based on a valid prescription. Your provider will discuss the benefits and risks of compounded medication during your consultation.

Report Side Effects

Call your provider or seek emergency care for any serious side effect. You may report suspected adverse reactions to the FDA at 1-800-FDA-1088 (MedWatch). You may also notify PepHaūs at safety@thepephaus.com.

Next steps

Questions before you start?

Every patient talks to a U.S.-licensed provider before receiving sermorelin. Your provider will review your complete medical history, discuss the information above, and confirm whether treatment is appropriate for you.

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This page is informational and does not replace the advice of a licensed healthcare provider. Last reviewed May 2026.