Safety information

What to know about NAD+.

Most patients tolerate NAD+ injections well. The most common reactions are mild flushing, warmth, or injection-site sensations that resolve within minutes. Below is the prescribing information your provider will review with you before you start. Take a moment to read it, save the page, and bring up anything that feels unclear during your consultation.

Flushing

Most common sensation. Usually mild, warm feeling that fades within minutes.

Slow injection

Inject slowly to minimize flushing and chest pressure. Stay seated for five minutes after.

Ask anytime

Message your provider any time in the portal. They respond within business hours.

Full prescribing information below

Indications

NAD+ (nicotinamide adenine dinucleotide) is a compounded coenzyme prescribed in support of cellular energy production, recovery, and metabolic health. Your U.S.-licensed provider makes the final determination whether NAD+ is appropriate based on your complete medical history.

Contraindications

Do not use NAD+ if you:
  • Are allergic to NAD+ or any of its ingredients
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have an active or recent diagnosis of cancer (theoretical concern; discuss with your oncologist)
  • Have a known history of severe asthma or hypersensitivity to vitamin B-complex compounds

Warnings & Precautions

The following risks should be discussed with your provider before starting and monitored throughout treatment:

  • Injection-site reactions

    Mild redness, warmth, or itching at the injection site is common and usually resolves within hours.

  • Flushing or chest pressure

    Some patients experience transient flushing or a feeling of chest tightness during or after injection. Inject slowly and remain seated for 5 minutes after dosing.

  • Theoretical concerns with active malignancy

    Because NAD+ is required by all cells, including cancer cells, the use of NAD+ injections in patients with active cancer should be discussed with your oncologist before starting.

  • Hypersensitivity reactions

    Discontinue and seek care for anaphylaxis, angioedema, or severe rash.

  • Patients with kidney or liver impairment

    Your provider will assess whether NAD+ is appropriate based on your kidney and liver function.

Common Side Effects

Commonly reported side effects of NAD+ injections are typically mild and short-lived:

Flushing
Nausea
Headache
Injection-site reaction
Fatigue
Mild dizziness
Transient chest pressure

Symptoms typically improve with time. Your provider will adjust your dose to minimize side effects.

Drug Interactions

NAD+ is not known to have major drug interactions. Still, tell your provider about every medication you take. That includes chemotherapy agents, immunosuppressants, and anti-seizure medications. They can review for potential concerns.

Pregnancy, Lactation, Fertility

NAD+ injections are not recommended during pregnancy or while breastfeeding because they have not been adequately studied in these populations. Discuss with your provider if you are pregnant or planning to become pregnant.

Storage & Handling

Store unopened vials refrigerated at 36 to 46°F (2 to 8°C). Once opened, follow the instructions provided with your shipment. Do not freeze. Protect from light. Dispose of used needles and syringes in an approved sharps container.

Compounded Medication Disclosure

This product is a compounded preparation dispensed by a U.S.-licensed 503A compounding pharmacy. Compounded drugs are not FDA-approved, are not evaluated by FDA for safety or effectiveness, and are prepared for an identified individual patient based on a valid prescription. Your provider will discuss the benefits and risks of compounded medication during your consultation.

Report Side Effects

Call your provider or seek emergency care for any serious side effect. You may report suspected adverse reactions to the FDA at 1-800-FDA-1088 (MedWatch). You may also notify PepHaūs at safety@thepephaus.com.

Next steps

Questions before you start?

Every patient talks to a U.S.-licensed provider before receiving NAD+. Your provider will review your complete medical history, discuss the information above, and confirm whether treatment is appropriate for you.

This page is informational and does not replace the advice of a licensed healthcare provider. Last reviewed May 2026.