NAD+ injections: the complete guide

What NAD+ is, what it does in every cell, why levels fall with age, how injections compare with IV drips and oral supplements, what to expect week by week, dosing, side effects and what it costs. Written for people who want the facts before they talk to a provider.

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U.S. licensed providers
Prescribed online
From $179/mo

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What NAD+ is
What it does
Injection vs IV vs oral
Who it is for
What to expect, week by week
Dosing and timing
Side effects and safety
Cost
FAQ
Latest articles

Quick answer

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme every cell uses to turn food into energy and to run its repair systems. Levels fall by roughly half between young adulthood and later life. A subcutaneous NAD+ injection at home raises levels far more reliably than an oral supplement, at a fraction of the cost of an IV drip. People use it for steadier energy, sharper focus and faster recovery. At PepHaus it is from $179 per month, prescribed by a licensed provider.

What NAD+ is

NAD+ is a molecule found in every living cell. It shuttles electrons in the reactions that convert food into ATP, the energy currency of the body, and it is the fuel for sirtuins and PARP enzymes, the proteins that repair DNA and regulate how cells age.

Levels are highest in your twenties and fall steadily after that. Stress, poor sleep, alcohol and inflammation all speed the decline. Lower NAD+ shows up as the slow drift people describe after 35: flatter energy, foggier focus, longer recovery from training or travel.

Compounded NAD+ for injection is prepared by a licensed 503A pharmacy under a provider's prescription. PepHaus ships it ready to use with a Certificate of Analysis on every vial.

What it does

Energy production. NAD+ is required at several steps of cellular respiration. More NAD+ means mitochondria can run those steps without a bottleneck.
DNA repair. PARP enzymes consume NAD+ to patch everyday DNA damage. When NAD+ is low, repair slows.
Sirtuin activity. The sirtuin family of enzymes, linked to healthy aging in research, only works when NAD+ is available.
Circadian rhythm. NAD+ levels and the body clock regulate each other, which is why many people notice sleep and daytime energy shift together.

Injection vs IV vs oral

	Subcutaneous injection	IV drip	Oral NAD+ or NMN/NR
Where	At home, 30 seconds	Clinic, 2 to 4 hours per session	At home
Absorption	Direct, bypasses the gut	Direct	Mostly broken down in digestion
Typical cost	From $179 a month	$300 to $1,000 per session	$40 to $150 a month
Side effects	Mild, brief	Flushing, chest tightness and nausea during the drip are common	Minimal
Prescription	Yes, provider supervised	Varies	No

IV drips deliver a large dose fast, which is why they often feel rough. Subcutaneous injections deliver a smaller amount several times a week, which most people find easier to tolerate and far easier to keep up.

Who NAD+ is for

Energy is flat by mid afternoon

Coffee stopped helping. You want steadier energy across the day, not a spike.

Focus drifts

Mental clarity is the second most reported change, usually within the first few weeks.

Recovery is slow

Training, travel and late nights take longer to bounce back from than they used to.

Spending on IV drips

You already know NAD+ works for you and want the same thing at home for a fraction of the cost.

Healthy aging, long game

You care about the repair side of the biology, not just how you feel this week.

Stacking with a GLP-1 or sermorelin

NAD+ pairs with weight loss or recovery plans. Your provider confirms the combination.

What to expect, week by week

Individual results vary. This is the pattern most people describe.

When	What people commonly report
Week 1 to 2	Mild flushing or warmth after the first few doses. Some notice better sleep quality almost immediately.
Week 3 to 6	Steadier daytime energy, sharper focus, fewer afternoon crashes.
Week 6 to 12	Faster recovery from training and travel. Mood often described as more even.
Month 3 and beyond	Benefits hold with consistent dosing. Many providers then move to a maintenance schedule.

Dosing and timing

Several times a week. Most providers prescribe 2 to 3 subcutaneous injections per week, some daily at a smaller dose.
Morning is usual. NAD+ supports daytime energy, so most people dose early rather than before bed.
Subcutaneous. Belly or thigh, rotating sites. Insulin size needle.
Go slow at first. Injecting slowly reduces the brief flushing some people feel.
Your provider sets the dose and adjusts it to your response.
Storage. Keep refrigerated and away from light. PepHaus vials ship cold and ready to use.

Side effects and safety

Subcutaneous NAD+ is generally well tolerated. What gets reported:

Common: warmth or flushing for a few minutes after the dose, injection site redness, mild nausea at first.
Less common: headache, brief dizziness, fatigue on the day of the first few doses.
Tell your provider about: anything that does not settle in a few days, or chest tightness that lasts beyond a few minutes.

NAD+ is not appropriate for everyone. People who are pregnant or breastfeeding, or with certain active conditions, are generally not candidates. A licensed provider reviews your history before anything is prescribed, and $0 is charged until you are approved.

What NAD+ costs

6-Month Plan

$179/mo

Billed $1,074.60 every 6 months. Save $119. Matches the window where results build.

Quarterly Plan

$189/mo

Billed $567.15 every 3 months. Save $30 compared with monthly.

Monthly

$199/mo

Billed monthly. Most flexible.

Every plan includes the provider visit, a 30-day supply of compounded NAD+, supplies, a Certificate of Analysis on every vial and free expedited shipping. No insurance needed. Full breakdown on the NAD+ cost page.

Frequently asked questions

What is NAD+?

NAD+ is a coenzyme every cell uses to produce energy and run its repair systems. Levels fall with age, stress and poor sleep.

What does an NAD+ injection do?

It raises NAD+ levels directly, bypassing digestion. People use it for steadier energy, sharper focus, faster recovery and support for healthy aging.

Is an NAD+ injection better than an IV drip?

An IV delivers a large dose in one sitting and often causes flushing and nausea during the drip. Subcutaneous injections deliver smaller doses several times a week at home, which most people tolerate better and find easier to keep up. They also cost a fraction of what clinics charge per drip.

Do oral NAD+ supplements work?

Oral NAD+ is largely broken down in digestion. Precursors like NMN and NR raise levels modestly. Injection delivers NAD+ itself, directly.

How often do you inject NAD+?

Most providers prescribe 2 to 3 subcutaneous injections a week, some daily at a smaller dose. Your provider sets the schedule.

What are the side effects of NAD+ injections?

Brief warmth or flushing after the dose, injection site redness and mild nausea at first are the most common. Injecting slowly reduces flushing.

How long until NAD+ works?

Sleep changes are often reported in the first two weeks. Energy and focus changes are usually reported between weeks 3 and 6. Individual results vary.

How much do NAD+ injections cost?

At PepHaus, NAD+ is from $179 per month on the 6-month plan, $189 quarterly, or $199 monthly, with the provider visit, supplies and free shipping included.

Is compounded NAD+ FDA approved?

No. Compounded medications are prepared for individual patients by licensed pharmacies under a provider's prescription and are not FDA approved products. Every PepHaus vial ships with a Certificate of Analysis.

Latest NAD+ articles

New articles on NAD+ are published on the PepHaus journal every day.

See if NAD+ is right for you

A short online visit, a licensed provider review, and nothing charged until you are approved.

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