Semaglutide vs tirzepatide: which is right for you?
Two weekly GLP-1 treatments, two price points. Here is how they compare on how they work, what the research shows and what each one costs at PepHaus.
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Quick answer
Both are one weekly injection that helps quiet cravings and support weight management. Semaglutide activates GLP-1 receptors and is one of the most studied GLP-1 treatments; at PepHaus it starts at $152/mo. Tirzepatide activates both GIP and GLP-1 receptors in one shot; it starts at $215/mo. A U.S. licensed provider reviews your history and recommends the one that fits you. No insurance needed.
Semaglutide vs tirzepatide side by side
| Semaglutide | Tirzepatide | |
|---|---|---|
| How it works | GLP-1 receptor agonist | Dual action, GIP plus GLP-1 |
| How often | One shot a week | One shot a week |
| 6-month plan | $152/mo (billed $912.60) | $215/mo (billed $1,291) |
| Quarterly plan | $160/mo | $227/mo |
| Monthly plan | $169/mo | $239/mo |
| Research highlight | One of the most studied GLP-1 treatments for weight loss | About 20% average weight loss at 15 mg over 72 weeks in SURMOUNT-1 |
| Dosing | Starts low, advances as tolerated, same price at every dose | Starts low, steps up when you are ready |
| Included | Provider visit, medication, supplies, free cold shipping | Provider visit, medication, supplies, free cold shipping |
| Availability | All 50 states plus DC | All 50 states plus DC |
SURMOUNT-1 studied the FDA approved tirzepatide product alongside diet and activity changes, not compounded tirzepatide. Individual results vary.
How each medication works
Semaglutide
Semaglutide is a GLP-1 receptor agonist. Activating GLP-1 receptors helps you feel full sooner, slows stomach emptying and reduces overall food intake. Patients describe quieter cravings, portions that satisfy and steadier energy through the afternoon. Eating less takes less effort.
Tirzepatide
Tirzepatide works on two pathways in one shot. It activates both GIP and GLP-1 receptors, which act on appetite and fullness. Patients describe the food noise going quiet and the pull toward the pantry fading, so eating less finally feels doable.
Both are given as one small weekly injection into the fat layer just under the skin, in the belly or upper thigh. From there the dose is absorbed slowly, which is why one shot lasts a week. It takes about 10 seconds.
What the research shows
Semaglutide is one of the most clinically studied GLP-1 medications for weight management. It has a long track record, and patients often see their strongest results at 4 to 6 months, so giving it time pays off.
Tirzepatide adds a second pathway. In SURMOUNT-1, a 72-week trial of the FDA approved tirzepatide product, adults on 15 mg lost an average of about 20% of body weight alongside diet and activity changes. Individual results vary, and month one is about adapting, not the finish line.
Both are strong, well researched options. The better choice for you depends on your health history, your goals and your budget, and that is exactly what your provider reviews.
Price comparison
Semaglutide is the lower priced option at PepHaus, starting at $152 per month. Tirzepatide starts at $215 per month. Both prices are on the 6-month plan and include the provider visit, medication, syringes and supplies, a Certificate of Analysis and free cold shipping.
No insurance is needed for either. $0 is due at intake, and you are only charged if a provider prescribes.
Which one fits you?
Semaglutide may suit you if you are
- Starting your first GLP-1 and want the most studied option
- Watching your budget and want the lowest monthly price
- Happy to build results steadily over 4 to 6 months
- Looking for one fixed price at any dose
Tirzepatide may suit you if you are
- Curious about dual action support in a single shot
- Dealing with loud, constant food noise
- Ready to invest a bit more in a two pathway approach
- Working with your provider to step up over time
The first timer
You have never tried a GLP-1 and want a well known starting point. Semaglutide is a natural place to begin.
The researcher
You read every study before you buy anything. Both options give you plenty to read, and your provider can walk you through it.
The snack drawer regular
Afternoon cravings run your day. Either medication is designed to help quiet them.
The decision avoider
You do not want to choose alone. Answer the intake honestly and a licensed provider recommends what fits.
Can you switch between them?
Yes. If you are on tirzepatide and want to move to semaglutide, message your provider through your dashboard and they will help you transition safely if it is appropriate for you. If your provider decides one medication is not the right fit, they may suggest the other.
How to get started
- 5-minute online visit. A short intake from your phone. No waiting room, no phone tag.
- Provider review. A U.S. licensed provider reviews your intake, usually within 24 hours. $0 is charged at this step.
- Shipped cold. Compounded by a licensed U.S. pharmacy and shipped to your door.
- Care on tap. Message your care team anytime in the portal.
Both treatments are available in all 50 U.S. states plus the District of Columbia. See the states we serve page, or go straight to semaglutide or tirzepatide.
Frequently asked questions
What is the difference between semaglutide and tirzepatide?
Semaglutide activates GLP-1 receptors. Tirzepatide activates both GIP and GLP-1 receptors in one weekly shot. Both help you feel full sooner and quiet cravings.
Which is cheaper, semaglutide or tirzepatide?
At PepHaus, semaglutide starts at $152 per month and tirzepatide starts at $215 per month, both on the 6-month plan. Each price includes the provider visit, medication, supplies and free cold shipping.
Are both taken once a week?
Yes. Both are one small subcutaneous injection a week, on the same day each week, in the belly or upper thigh.
Can I switch from tirzepatide to semaglutide?
Yes. Message your provider through your dashboard and they will help you transition safely if it is appropriate for you.
How do I know which one is right for me?
Complete the online intake. A U.S. licensed provider reviews your health history and goals and decides which treatment is appropriate. $0 is due at intake.
Are compounded semaglutide and tirzepatide FDA approved?
No. Compounded medications are prepared for individual patients by licensed pharmacies under a provider's prescription and are not FDA approved products. They use the same active ingredients, and every batch ships with a Certificate of Analysis.
Do I need insurance?
No. PepHaus is cash pay. One flat monthly price covers the provider visit, medication, supplies and shipping.
What side effects are common?
The most common early effects are nausea, reduced appetite and mild GI changes, usually mild and temporary, and most noticeable after a dose change. Your provider starts you low and adjusts gradually.
Let a provider help you choose
Semaglutide from $152/mo. Tirzepatide from $215/mo. Charged only if prescribed.
Start with semaglutideStart with tirzepatide